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This finding challenges the idea that communicating genomic screening results by mail alone is sufficient to meet patients' needs. Nevertheless, a significant proportion of patients also reported difficulty understanding some aspects of their results. Raju, Dheeraj Nawalinski, Kelsey Frangos, Suzanne Kung, David Zager. These data suggest most patients value receiving negative genomic screening results and are comfortable receiving their results by mail. Nonetheless, many respondents had questions about their genomic screening results (28%) and would have preferred to receive their screening results in person (18%). The vast majority of respondents valued the information they received, with 98% of respondents reporting that negative genomic screening results were valuable and 72% indicating they would recommend genomic screening to others. One thousand four hundred forty-two participants completed the survey (84.2%). Genetic counselors were available to assist with the interpretation of screening results. Although multiple studies have examined how patients understand positive genomic screening results, few data exist regarding patient engagement with negative screening results.Īn 82-item survey was administered to 1712 individuals who received negative genomic screening results by mail following evaluation of 109 medically actionable genes. Dvoskin, Rachel, Bollinger, Juli, McCague, Allison, Shpritz, Barnett, Brandt, Jason, Mathews, Debra Molecular Genetics & Genomic Medicine Pacyna, Joel, Kullo. Conclusions: Increased RDW was significantly associated with increased long-term all-cause mortality in diabetic patients after PCI.As genomic screening is incorporated into a wider array of clinical settings, it is critical that we understand how patients may respond to a various screening results. 8-Apr IRB & Ethical considerations in human subjects research. Mavis Kelsey estimated Net Worth, Biography, Age, Height, Dating. Multivariate analysis identified high RDW as being associated with all-cause mortality (hazard ratio, 2.56 95% confidence interval, 1.12–6.62 P=0.025). More about Kullo Must Bio, Wiki, Net Worth, Salary, Height, Age, Relationship, Career. The cumulative incidence of all-cause death was significantly higher in the high RDW group than in the low RDW group (log-rank P=0.0015). Twenty-nine patients (5.2%) died during follow up. Patients with high RDW were more likely to be older, show dyslipidemia and have a lower ejection fraction and decreased hemoglobin level. Mean duration of follow up was 3.9 years. All-cause mortality rates were compared between groups. Patients were divided into 2 groups according to median RDW at baseline (13.1%): a high RDW group (mean RDW, 14.0% interquartile range, 13.3–14.2%) and a low RDW group (mean RDW, 12.6% interquartile range, 12.4–12.9%). Methods and Results: Subjects comprised 560 consecutive diabetic patients (mean age, 66.6 years male, 80%) with stable CAD who had undergone elective percutaneous coronary intervention (PCI).
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However, the relationship between RDW and long-term outcome in diabetic patients with coronary artery disease (CAD) is unclear. Diabetes mellitus increases oxidative stress and vascular inflammation, which accelerate atherosclerosis.
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Department of Cardiovascular Medicine, Juntendo University School of Medicineīackground: Red blood cell distribution width (RDW) is a novel prognostic marker that reflects oxidative stress and chronic inflammation in patients with cardiovascular disease.